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Immune response

Antibodies show effectiveness for HIV prevention and promise for treatment and cure

The ability of HIV to mutate has been a major challenge to vaccine development. As the body produces antibodies to target the outer HIV envelope protein, this protein changes, thwarting…

Suboptimal ART adherence associated with greater inflammation in patients with HIV

Recently published findings indicate that suboptimal adherence to ART is associated with activation of coagulation and enhanced residual inflammation among patients with HIV, even if patients have already achieved virologic…

Selective suppression of inflammation could deplete HIV and control HIV activation

A class of anti-inflammatory drugs already FDA-approved for rheumatoid arthritis could “purge” the reservoir of infected immune cells in people infected by HIV, according to new research. When culturing cells…

CATIE: December 2017 issue of TreatmentUpdate now online

TreatmentUpdate is CATIE’s flagship digest on cutting-edge developments in HIV and hepatitis C research and treatment. TreatmentUpdate 223: Inflammation and HIV, December 2017 issue is available at: http://www.catie.ca/en/treatmentupdate/treatmentupdate-223

Baseline CD4 count biggest factor in long-term immune system improvements after starting HIV therapy

Pre-treatment CD4 cell count is the most important factor in immune recovery following the initiation of combination antiretroviral therapy (cART), according to the results of a large observation study published…

Age and T-cell markers not linked in HIV patients

Older age and HIV status independently affect an individual’s immune system. Yet, there is no evidence that HIV infection and advancing age together accelerate changes in age-related T-cell markers, according…

Immune cells turn back time to achieve memory

Memory T cells' genes poised to respond years after infection/vaccination Memory T cells earn their name by embodying the memory of the immune system -- they help the body remember…

Anti-aging protein could be targeted to rejuvenate immune cells

New study explains what happens when the immune system ages San Francisco, CA, November 30, 2017—Anti-aging proteins have long been shown to protect against age-related diseases, such as cancer, neurodegeneration,…

Preventing HIV at the initial stages of infection

In a project funded by the Austrian Science Fund FWF, Doris Wilflingseder investigates the initial stages of HIV infection, a period when the immune system might still stop the virus.…

Four big insights into HIV/AIDS that provide hope of finding a vaccine

HIV remains one of the continent’s most intractable health challenges. Tremendous progress is being made to understand the virus, the immune mechanisms that contribute to its control and for new…

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