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Basic science

HIV protein function that slows migration of T cells also improves viral survival

"Patch" of Nef protein amino acids appears to help virus evade the immune response in animal model A study from a Massachusetts General Hospital (MGH) research team has identified the…

Cell size and cell-cycle states play key decision-making roles in HIV

Thanks to the development of antiretroviral drugs, human immunodeficiency virus (HIV) is considered a manageable chronic disease today. However, if left undiagnosed or untreated, HIV can develop into AIDS (acquired…

AIDS – an approach for targeting HIV reservoirs

Current HIV treatments need to be taken for life by those infected as antiretroviral therapy is unable to eliminate viral reservoirs lurking in immune cells. Institut Pasteur scientists have identified…

Uncovering a key mechanism in assembly of Avian Sarcoma Virus, a relative of HIV-1

This 100-year-old oncogenic virus often used to study HIV-1, and understanding the molecular basis of binding informs ways to prevent retroviral replication, including the HIV retrovirus. BIRMINGHAM, Ala. - A…

Hepatitis: Liver failure attributable to compromised blood supply

In severe cases, a viral hepatitis infection can result in liver failure. A team from the Technical University of Munich (TUM) has now discovered how this occurs: by immune cells…

Roadmap reveals shortcut to recreate key HIV antibody for vaccines

With new insights about the antibody's pathway, researchers can bypass a previous hurdle DURHAM, N.C. -- HIV evades the body's immune defenses through a multitude of mutations, and antibodies produced…

Infectivity of different HIV-1 strains may depend on which cell receptors they target

Distinct HIV-1 strains may differ in the nature of the CCR5 molecules to which they bind, affecting which cells they can infect and their ability to enter cells, according to…

Eliminating the latent reservoir of HIV

A new study suggests that a genetic switch that causes latent HIV inside cells to begin to replicate can be manipulated to completely eradicate the virus from the human body.…

Investigators discover compounds that block reactivation of latent HIV-1

Washington, DC - December 3, 2018 - A team of investigators from the University of Pittsburgh has identified compounds that block the reactivation of latent HIV-1 in a human cell…

Focus on resistance to HIV offers insight into how to fight the virus

Of the 40 million people around the world infected with HIV, less than one per cent have immune systems strong enough to suppress the virus for extended periods of time.…

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