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Basic science

Novel genomic tools provide new insight into human immune system

When the body is under attack from pathogens, the immune system marshals a diverse collection of immune cells to work together in a tightly orchestrated process and defend the host…

Antibodies show effectiveness for HIV prevention and promise for treatment and cure

The ability of HIV to mutate has been a major challenge to vaccine development. As the body produces antibodies to target the outer HIV envelope protein, this protein changes, thwarting…

Gene therapy using CAR T-cells could provide long-term protection against HIV

FINDINGS Through gene therapy, researchers engineered blood-forming stem cells (hematopoietic stem/progenitor cells, or HSPCs) to carry chimeric antigen receptor (CAR) genes to make cells that can detect and destroy HIV-infected…

Why finding new HIV targets takes so long: Some basics about basic research

Although great strides have been made at combating human immunodeficiency virus, leading to better quality of life and a longer life expectancy for those living with the virus, significant problems…

Selective suppression of inflammation could deplete HIV and control HIV activation

A class of anti-inflammatory drugs already FDA-approved for rheumatoid arthritis could “purge” the reservoir of infected immune cells in people infected by HIV, according to new research. When culturing cells…

Anti-virus protein in humans may resist transmission of HIV-1 precursor from chimps

Cross-transmission of HIV-1 precursor may have started in people with unstable forms of the protein In humans, an anti-virus protein known as APOBEC3H may defend against cross-species transmission from chimpanzees…

Using viruses to fight viruses: new approach eliminates ‘dormant’ HIV-infected cells

While Ottawa researchers are known for their work on cancer-fighting viruses, one team is applying these viruses to a new target: HIV. Researchers at The Ottawa Hospital and the University…

EFGCP Conference Coming Up in February

The upcoming conference of the European Forum for Good Clinical Practice holds its next conference in Brussels in February 2018. The conference will pay special attention to the consequences of…

Immune cells turn back time to achieve memory

Memory T cells' genes poised to respond years after infection/vaccination Memory T cells earn their name by embodying the memory of the immune system -- they help the body remember…

A close look at how HIV-fighting proteins slow the virus down

When HIV attacks, it inserts a permanent copy of its genetic material into the infected person’s genome. But the body has evolved mechanisms to fight back, including a cellular process…

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