Basic Science
Basic Science 10/01/2011
Sangamo BioSciences plans to present the first human clinical data from its Phase 1 trials of SB-728-T in HIV/AIDS in the first quarter of 2011
Sangamo is developing SB-728-T, a ZFN approach to the treatment of HIV/AIDS and has an ongoing Phase 1/2 and two Phase 1 clinical trials to evaluate the safety and clinical efficacy of this approach in CD4+ T-cells.
Basic Science 24/12/2010
Discovery highlights potential to combat HIV/AIDS
Researchers have discovered how HIV binds to and destroys a specific human antiviral protein called APOBEC3F.
Basic Science 16/12/2010
New finding sheds light on how HIV eludes treatment by mutating
Understanding exactly how HIV cells change as they reproduce is key to developing better tests and treatments for patients.
Basic Science 13/12/2010
New groundbreaking research advances understanding of HIV
Groundbreaking research by University of Victoria biomedical engineer Stephanie Willerth has significantly advanced the understanding of HIV and how to treat it.
Basic Science 01/12/2010
Not all HIV viruses are bad for the immune system
Researchers have shown why, in a minority of HIV patients, immune function improves despite a lack of response to standard anti-retroviral treatment. In these cases the virus has lost its ability to kill immune cells.
Basic Science 01/12/2010
Human protein tetherin disables production of new infectious HIV
A human cellular protein known as bone marrow stromal cell antigen-2 (BST02) -- also called tetherin -- can interfere with maturation and release of newly produced HIV viral particles, thereby offering protection against infection of additional cells.
Basic Science 25/11/2010
Scientists reveal long-standing mystery about HIV infection
Scientists have solved a long-standing mystery about HIV infection-namely how HIV promotes the death of CD4 T cells.
Basic Science 20/11/2010
Improving immune system to defend against HIV infection
"We are homing in on a better understanding of what the immune system needs to do in order to mount an effective defense against HIV."
Basic Science 20/11/2010
Study refocuses on rare group of neutralizing antibodies against HIV
Although people infected with HIV produce many antibodies against the protein encapsulating the virus, most of these antibodies are strangely ineffective at fighting the disease.
Basic Science 20/11/2010
Protein discovery helps explain the body’s failure to kill HIV
Researchers have discovered a protein produced by HIV that keeps infected cells from signaling the immune system that they are harboring the virus and should be killed.
Basic Science 15/11/2010
Study explains why HIV so tough to beat
Scientists have solved one of the great mysteries of the HIV/AIDS virus: why it is so successful at breaking down the body's resistance.
Basic Science 14/11/2010
NIH scientists shed light on immune reconstitution inflammatory syndrome (IRIS)
Newly published research sheds light on a poorly understood, acute illness called IRIS that develops in some HIV-infected individuals soon after they begin antiretroviral therapy. IRIS is a significant problem in the treatment of HIV patients.
Basic Science 11/11/2010
X-rays illuminate the mechanism used by HIV to attack human DNA
Imperial scientists have made an important advance in understanding how retroviruses infect human cells.
Basic Science 06/11/2010
Researchers unravel a secret of HIV controllers
Five amino acids—tiny fragments of protein called HLA-B—are what separate an elite group of HIV-positive people who naturally do not progress to AIDS from those living with the virus who will invariably develop AIDS without lifelong antiretroviral treatment.
Basic Science 06/11/2010
Isentress might reduce risk of a “fatty” liver from protease inhibitors
A new laboratory study suggests that the integrase inhibitor Isentress (raltegravir) could prevent the accumulation of excess fat in the liver (steatosis) that results from protease inhibitor (PI) therapy.
Basic Science 24/10/2010
CD4 T cells from "elite controllers" resist infection by HIV
Their CD4 cells have a 10- to 100-fold higher expression of p21, a host protein originally described as a product of a tumor suppressor gene. Experiments show that modulating the intracellular level of p21 affects the level of HIV replication in the cell.
Basic Science 14/10/2010
New look at multitalented protein sheds light on mysteries of HIV
New insights into the HIV infection process may now be possible through a research method, where scientists have glimpsed an important protein molecule's behavior with unprecedented clarity.
Basic Science 08/10/2010
Study details structure of potential target for HIV and cancer drugs
The high-resolution structure sheds light on how the molecule functions and could point to ways to control its activity, potentially locking out HIV and stalling cancer's spread.
Basic Science 23/09/2010
HIV infection mystery revealed
Scientists have found out how HIV entered a group of cells in which the virus tends to persist in spite of antiviral treatment that reduces the virus to undetectable levels.
Basic Science 20/09/2010
Researchers discover HIV mechanism to resist AZT drug
Virus hijacks a common molecule to do the job.
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