At a time when the need to test novel medication in HIV positive treatment naïve individuals is strong, and in which the ethical scrutiny in industrialised countries renders the conduction of such trials a complex and costly endeavour, resulting in an increased number of clinical trials in marginalized populations and resource poor countries, the EATG decided to convey its own perspective through a Position Paper on Ethics of Clinical Trials in vulnerable groups. This Position Paper differs in several ways from other similar papers written on the subject for the reason that it intends to take a broader look at the community perspective of this complex subject. The EATG’s point of view goes beyond the trials themselves to embrace the person’s well being and treatment after the trial, his/her life conditions during the duration of the study, and the benefit of the research to the community as a whole. Below is a short overview highlighting the most important aspects.